TOV-112D
CRL-3593 ™
TOV-112D is a cell exhibiting epithelial morphology that was isolated from the ovary of a 42-year-old, female with primary malignant adenocarcinoma. This cell line was deposited by University of Montreal. This product is an ATCC manufactured and accessioned progeny of ATCC CRL-11731 cited in US Pat. No. 5,710,038.
Product category
Human cells
Organism
Homo sapiens, human
Morphology
epithelial
Tissue
Ovary
Disease
Primary Malignant Adenocarcinoma; Grade 3, stage IIIC,
Applications
Cancer research
Product format
Frozen
Storage conditions
Vapor phase of liquid nitrogen
Growth properties
Adherent
Derivation
This cell line was initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.
Age
42 years
Gender
Female
Clinical data
This cell line was initiated in October of 1992 from a patient with early onset ovarian cancer.
Karyotype
52, XX, add(X)(p22), +add(1)(p22), +add(1)(p22), +2, +9, +12, add(15)(p11), +17
Tumorigenic
Yes;
The cells are tumorigenic in nude mice and form colonies in soft agar
Oncogene
her2/neu+; p53 (mutated, Arg --> His mutation at exon 6, codon 175)
Genes expressed
keratin
Comments
Unlike TOV-21G (ATCC CRL-11730) and OV-90 (ATCC CRL-11732), the TOV-112D cell line does not exhibit a deletion at chromosome 3p24.
