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平臺(tái)編號(hào)：bio-131653
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細(xì)胞信息： PC14
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規(guī)格：1×10?cells/T25培養(yǎng)瓶
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注意事項(xiàng)：僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的不可用于人類或動(dòng)物的臨床診斷或治療，非藥用，非食用（產(chǎn)品信息以出庫(kù)為準(zhǔn)）
人肺腺癌細(xì)胞PC14
細(xì)胞名稱：人肺腺癌細(xì)胞PC14
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細(xì)胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運(yùn)輸方式：常溫保溫運(yùn)輸；干冰運(yùn)輸
安全等級(jí)：1
用途限制：僅供科研2類
培養(yǎng)體系：DMEM高糖培養(yǎng)基+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
簡(jiǎn)介：人肺腺癌細(xì)胞PC14取自45歲男性肺腺癌患者淋巴轉(zhuǎn)移組織，貼壁培養(yǎng)。該細(xì)胞源于ECACC
注釋
Part of:Cancer Cell Line Encyclopedia(CCLE)project.
Part of:COSMIC cell lines project.
From:Immuno-Biological Laboratories(IBL);Tokyo;Japan.
Microsatellite instability:Stable(MSS)(Sanger).
Omics:Deep exome analysis.
Omics:Deep quantitative proteome analysis.
Omics:Deep RNAseq analysis.
Omics:DNA methylation analysis.
Omics:SNP array analysis.
Omics:Transcriptome analysis.
基因突變
EGFR p.Glu746_Ala750del(c.2235_2249del15)(PubMed=16105816).
Homozygous for TP53 p.Arg248Gln(c.743G>A)(PubMed=15901131;Cosmic-CLP).
HLA信息
STR信息
Amelogenin X
CSF1PO 11
D5S818 11
D7S820 10,11(Cosmic-CLP)
10(ECACC;PubMed=11416159)
D8S1179 11,15
D13S317 8
D16S539 9
D18S51 15
D21S11 29,30
FGA 23,25
TH01 7
TPOX 11
vWA 17
參考文獻(xiàn)
PubMed=27397505;DOI=10.1016/j.cell.2016.06.017
Iorio F.,Knijnenburg T.A.,Vis D.J.,Bignell G.R.,Menden M.P.,Schubert M.,Aben N.,Goncalves E.,Barthorpe S.,Lightfoot H.,Cokelaer T.,Greninger P.,van Dyk E.,Chang H.,de Silva H.,Heyn H.,Deng X.,Egan R.K.,Liu Q.,Mironenko T.,Mitropoulos X.,Richardson L.,Wang J.,Zhang T.,Moran S.,Sayols S.,Soleimani M.,Tamborero D.,Lopez-Bigas N.,Ross-Macdonald P.,Esteller M.,Gray N.S.,Haber D.A.,Stratton M.R.,Benes C.H.,Wessels L.F.A.,Saez-Rodriguez J.,McDermott U.,Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=30894373;DOI=10.1158/0008-5472.CAN-18-2747
Dutil J.,Chen Z.,Monteiro A.N.,Teer J.K.,Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res.79:1263-1273(2019)
PubMed=31068700;DOI=10.1038/s41586-019-1186-3
Ghandi M.,Huang F.W.,Jane-Valbuena J.,Kryukov G.V.,Lo C.C.,McDonald E.R.III,Barretina J.,Gelfand E.T.,Bielski C.M.,Li H.,Hu K.,Andreev-Drakhlin A.Y.,Kim J.,Hess J.M.,Haas B.J.,Aguet F.,Weir B.A.,Rothberg M.V.,Paolella B.R.,Lawrence M.S.,Akbani R.,Lu Y.,Tiv H.L.,Gokhale P.C.,de Weck A.,Mansour A.A.,Oh C.,Shih J.,Hadi K.,Rosen Y.,Bistline J.,Venkatesan K.,Reddy A.,Sonkin D.,Liu M.,Lehar J.,Korn J.M.,Porter D.A.,Jones M.D.,Golji J.,Caponigro G.,Taylor J.E.,Dunning C.M.,Creech A.L.,Warren A.C.,McFarland J.M.,Zamanighomi M.,Kauffmann A.,Stransky N.,Imielinski M.,Maruvka Y.E.,Cherniack A.D.,Tsherniak A.,Vazquez F.,Jaffe J.D.,Lane A.A.,Weinstock D.M.,Johannessen C.M.,Morrissey M.P.,Stegmeier F.,Schlegel R.,Hahn W.C.,Getz G.,Mills G.B.,Boehm J.S.,Golub T.R.,Garraway L.A.,Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
PubMed=31978347;DOI=10.1016/j.cell.2019.12.023
Nusinow D.P.,Szpyt J.,Ghandi M.,Rose C.M.,McDonald E.R.III,Kalocsay M.,Jane-Valbuena J.,Gelfand E.,Schweppe D.K.,Jedrychowski M.,Golji J.,Porter D.A.,Rejtar T.,Wang Y.K.,Kryukov G.V.,Stegmeier F.,Erickson B.K.,Garraway L.A.,Sellers W.R.,Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402(2020)
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細(xì)胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運(yùn)輸方式：常溫保溫運(yùn)輸；干冰運(yùn)輸
安全等級(jí)：1
用途限制：僅供科研2類
培養(yǎng)體系：DMEM高糖培養(yǎng)基+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
簡(jiǎn)介：人肺腺癌細(xì)胞PC14取自45歲男性肺腺癌患者淋巴轉(zhuǎn)移組織，貼壁培養(yǎng)。該細(xì)胞源于ECACC
注釋
Part of:Cancer Cell Line Encyclopedia(CCLE)project.
Part of:COSMIC cell lines project.
From:Immuno-Biological Laboratories(IBL);Tokyo;Japan.
Microsatellite instability:Stable(MSS)(Sanger).
Omics:Deep exome analysis.
Omics:Deep quantitative proteome analysis.
Omics:Deep RNAseq analysis.
Omics:DNA methylation analysis.
Omics:SNP array analysis.
Omics:Transcriptome analysis.
基因突變
EGFR p.Glu746_Ala750del(c.2235_2249del15)(PubMed=16105816).
Homozygous for TP53 p.Arg248Gln(c.743G>A)(PubMed=15901131;Cosmic-CLP).
HLA信息
STR信息
Amelogenin X
CSF1PO 11
D5S818 11
D7S820 10,11(Cosmic-CLP)
10(ECACC;PubMed=11416159)
D8S1179 11,15
D13S317 8
D16S539 9
D18S51 15
D21S11 29,30
FGA 23,25
TH01 7
TPOX 11
vWA 17
參考文獻(xiàn)
PubMed=27397505;DOI=10.1016/j.cell.2016.06.017
Iorio F.,Knijnenburg T.A.,Vis D.J.,Bignell G.R.,Menden M.P.,Schubert M.,Aben N.,Goncalves E.,Barthorpe S.,Lightfoot H.,Cokelaer T.,Greninger P.,van Dyk E.,Chang H.,de Silva H.,Heyn H.,Deng X.,Egan R.K.,Liu Q.,Mironenko T.,Mitropoulos X.,Richardson L.,Wang J.,Zhang T.,Moran S.,Sayols S.,Soleimani M.,Tamborero D.,Lopez-Bigas N.,Ross-Macdonald P.,Esteller M.,Gray N.S.,Haber D.A.,Stratton M.R.,Benes C.H.,Wessels L.F.A.,Saez-Rodriguez J.,McDermott U.,Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=30894373;DOI=10.1158/0008-5472.CAN-18-2747
Dutil J.,Chen Z.,Monteiro A.N.,Teer J.K.,Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res.79:1263-1273(2019)
PubMed=31068700;DOI=10.1038/s41586-019-1186-3
Ghandi M.,Huang F.W.,Jane-Valbuena J.,Kryukov G.V.,Lo C.C.,McDonald E.R.III,Barretina J.,Gelfand E.T.,Bielski C.M.,Li H.,Hu K.,Andreev-Drakhlin A.Y.,Kim J.,Hess J.M.,Haas B.J.,Aguet F.,Weir B.A.,Rothberg M.V.,Paolella B.R.,Lawrence M.S.,Akbani R.,Lu Y.,Tiv H.L.,Gokhale P.C.,de Weck A.,Mansour A.A.,Oh C.,Shih J.,Hadi K.,Rosen Y.,Bistline J.,Venkatesan K.,Reddy A.,Sonkin D.,Liu M.,Lehar J.,Korn J.M.,Porter D.A.,Jones M.D.,Golji J.,Caponigro G.,Taylor J.E.,Dunning C.M.,Creech A.L.,Warren A.C.,McFarland J.M.,Zamanighomi M.,Kauffmann A.,Stransky N.,Imielinski M.,Maruvka Y.E.,Cherniack A.D.,Tsherniak A.,Vazquez F.,Jaffe J.D.,Lane A.A.,Weinstock D.M.,Johannessen C.M.,Morrissey M.P.,Stegmeier F.,Schlegel R.,Hahn W.C.,Getz G.,Mills G.B.,Boehm J.S.,Golub T.R.,Garraway L.A.,Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
PubMed=31978347;DOI=10.1016/j.cell.2019.12.023
Nusinow D.P.,Szpyt J.,Ghandi M.,Rose C.M.,McDonald E.R.III,Kalocsay M.,Jane-Valbuena J.,Gelfand E.,Schweppe D.K.,Jedrychowski M.,Golji J.,Porter D.A.,Rejtar T.,Wang Y.K.,Kryukov G.V.,Stegmeier F.,Erickson B.K.,Garraway L.A.,Sellers W.R.,Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402(2020)
