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平臺編號：bio-129693
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細胞信息： LC-2
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規(guī)格：1×10?cells/T25培養(yǎng)瓶
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用途：細胞系
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服務費用：
加載中…… - 訂購
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注意事項：僅用于科學研究或者工業(yè)應用等非醫(yī)療目的不可用于人類或動物的臨床診斷或治療，非藥用，非食用（產(chǎn)品信息以出庫為準）
人肺腺癌細胞LC-2
細胞名稱：人肺腺癌細胞LC-2
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運輸方式：常溫保溫運輸；干冰運輸
安全等級：1
用途限制：僅供科研3類
培養(yǎng)體系：DMEM高糖（HYCLONE SH30022.01)+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
簡介：人肺腺癌細胞LC-2取自51歲女性供體。
注釋：Part of:Cancer Cell Line Encyclopedia(CCLE)project.
Part of:COSMIC cell lines project.
Population:Japanese.
Doubling time:58 hours,at 32th passage(PubMed=8291444).
Microsatellite instability:Stable(MSS)(Sanger).
Omics:Deep exome analysis.
Omics:DNA methylation analysis.
Omics:SNP array analysis.
Omics:Transcriptome analysis.
基因突變
Gene fusion CCDC6-RET(RET/PTC1)(PubMed=23578175).
EGFR p.Leu858Arg(c.2573T>G)(ClinVar=VCV000016609)(PubMed=16105816).
EGFR p.Glu746_Ala750del(PubMed=23154560).
Homozygous for TP53 p.Ser241Cys(c.722C>G)(ClinVar=VCV000177791)(Cosmic-CLP).
HLA信息：/
STR信息
Amelogenin X
CSF1PO 10,11
D5S818 10
D7S820 11
D13S317 10,12
D16S539 9
TH01 7
TPOX 11
vWA 16,19
參考文獻
PubMed=23578175;DOI=10.1111/cas.12175
Suzuki M.,Makinoshima H.,Matsumoto S.,Suzuki A.,Mimaki S.,Matsushima K.,Yoh K.,Goto K.,Suzuki Y.,Ishii G.,Ochiai A.,Tsuta K.,Shibata T.,Kohno T.,Esumi H.,Tsuchihara K.
Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Cancer Sci.104:896-903(2013)
PubMed=27397505;DOI=10.1016/j.cell.2016.06.017
Iorio F.,Knijnenburg T.A.,Vis D.J.,Bignell G.R.,Menden M.P.,Schubert M.,Aben N.,Goncalves E.,Barthorpe S.,Lightfoot H.,Cokelaer T.,Greninger P.,van Dyk E.,Chang H.,de Silva H.,Heyn H.,Deng X.,Egan R.K.,Liu Q.,Mironenko T.,Mitropoulos X.,Richardson L.,Wang J.,Zhang T.,Moran S.,Sayols S.,Soleimani M.,Tamborero D.,Lopez-Bigas N.,Ross-Macdonald P.,Esteller M.,Gray N.S.,Haber D.A.,Stratton M.R.,Benes C.H.,Wessels L.F.A.,Saez-Rodriguez J.,McDermott U.,Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=30894373;DOI=10.1158/0008-5472.CAN-18-2747
Dutil J.,Chen Z.,Monteiro A.N.,Teer J.K.,Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res.79:1263-1273(2019)
細胞操作說明下載：細胞操作說明
產(chǎn)品規(guī)格：T25培養(yǎng)瓶x1；1.5ml凍存管x2
細胞數(shù)量：1x10^6；1x10^6
保存溫度：37℃；-198℃
運輸方式：常溫保溫運輸；干冰運輸
安全等級：1
用途限制：僅供科研3類
培養(yǎng)體系：DMEM高糖（HYCLONE SH30022.01)+10%FBS+1%三抗
培養(yǎng)溫度：37℃
二氧化碳濃度：5%
簡介：人肺腺癌細胞LC-2取自51歲女性供體。
注釋：Part of:Cancer Cell Line Encyclopedia(CCLE)project.
Part of:COSMIC cell lines project.
Population:Japanese.
Doubling time:58 hours,at 32th passage(PubMed=8291444).
Microsatellite instability:Stable(MSS)(Sanger).
Omics:Deep exome analysis.
Omics:DNA methylation analysis.
Omics:SNP array analysis.
Omics:Transcriptome analysis.
基因突變
Gene fusion CCDC6-RET(RET/PTC1)(PubMed=23578175).
EGFR p.Leu858Arg(c.2573T>G)(ClinVar=VCV000016609)(PubMed=16105816).
EGFR p.Glu746_Ala750del(PubMed=23154560).
Homozygous for TP53 p.Ser241Cys(c.722C>G)(ClinVar=VCV000177791)(Cosmic-CLP).
HLA信息：/
STR信息
Amelogenin X
CSF1PO 10,11
D5S818 10
D7S820 11
D13S317 10,12
D16S539 9
TH01 7
TPOX 11
vWA 16,19
參考文獻
PubMed=23578175;DOI=10.1111/cas.12175
Suzuki M.,Makinoshima H.,Matsumoto S.,Suzuki A.,Mimaki S.,Matsushima K.,Yoh K.,Goto K.,Suzuki Y.,Ishii G.,Ochiai A.,Tsuta K.,Shibata T.,Kohno T.,Esumi H.,Tsuchihara K.
Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Cancer Sci.104:896-903(2013)
PubMed=27397505;DOI=10.1016/j.cell.2016.06.017
Iorio F.,Knijnenburg T.A.,Vis D.J.,Bignell G.R.,Menden M.P.,Schubert M.,Aben N.,Goncalves E.,Barthorpe S.,Lightfoot H.,Cokelaer T.,Greninger P.,van Dyk E.,Chang H.,de Silva H.,Heyn H.,Deng X.,Egan R.K.,Liu Q.,Mironenko T.,Mitropoulos X.,Richardson L.,Wang J.,Zhang T.,Moran S.,Sayols S.,Soleimani M.,Tamborero D.,Lopez-Bigas N.,Ross-Macdonald P.,Esteller M.,Gray N.S.,Haber D.A.,Stratton M.R.,Benes C.H.,Wessels L.F.A.,Saez-Rodriguez J.,McDermott U.,Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=30894373;DOI=10.1158/0008-5472.CAN-18-2747
Dutil J.,Chen Z.,Monteiro A.N.,Teer J.K.,Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res.79:1263-1273(2019)
細胞操作說明下載：細胞操作說明
