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首頁>細胞CELL>示蹤細胞(GFP/LUC/RFP...)>人霍奇金淋巴瘤細胞KM-H2
人霍奇金淋巴瘤細胞KM-H2
    人霍奇金淋巴瘤細胞KM-H2
  • 平臺編號:bio-121951
  • 拉丁屬名: KM-H2
  • 規(guī)格:1×10?cells/T25培養(yǎng)瓶
  • 用途:細胞 系
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  • 注意事項:僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的不可用于人類或動物的臨床診斷或治療,非藥用,非食用(產(chǎn)品信息以出庫為準(zhǔn))

  細胞名稱:人霍奇金淋巴瘤細胞KM-H2

產(chǎn)品規(guī)格:T25培養(yǎng)瓶x1;1.5ml凍存管x2

細胞數(shù)量:1x10^6;1x10^6

保存溫度:37℃;-198℃

運輸方式:常溫保溫運輸;干冰運輸

安全等級:1

用途限制:僅供科研3類

培養(yǎng)體系:DMEM(HYCLONE SH30022.01)+10%FBS+1%三抗

培養(yǎng)溫度:37℃

二氧化碳濃度:5%

簡介:人霍奇金淋巴瘤細胞KM-H2取自37歲男性供體,懸浮培養(yǎng)。

注釋

Part of:Cancer Cell Line Encyclopedia(CCLE)project.

Part of:COSMIC cell lines project.

Part of:LL-100 blood cancer cell line panel.

Part of:MD Anderson Cell Lines Project.

Doubling time:~48 hours(DSMZ).

Microsatellite instability:Stable(MSS)(Sanger).

Omics:Cell surface proteome.

Omics:Deep exome analysis.

Omics:Deep RNAseq analysis.

Omics:DNA methylation analysis.

Omics:Protein expression by reverse-phase protein arrays.

Omics:SNP array analysis.

Omics:Transcriptome analysis.

Omics:Virome analysis using RNAseq.

Misspelling:KHM2/171877;In IPD-IMGT/HLA 15116.

Derived from sampling site:Pleural effusion.

基因突變

CIITA-C15orf65 gene fusion(PubMed=21368758).

PRRC2B-MGMT(BAT2L1-MGMT)gene fusion(PubMed=21368758)

HLA信息

Class I

HLA-A A*24:02

HLA-B B*15:01,52:01

HLA-C C*04:01,12:02

Class II

HLA-DP DPB1*02:01,05:01

HLA-DQ DQA1*03:01,05:05

DQB1*03:01,03:02

HLA-DR DRB1*04:65,11:01

DRB3*02:02

DRB4*01:03

STR信息

Amelogenin X

CSF1PO 10,14

D5S818 11,13

D7S820 10,11,12

D13S317 10,11

D16S539 9

TH01 7,9

TPOX 8,11,12(Cosmic-CLP)

8,10,11(DSMZ)

vWA 17,18

參考文獻

PubMed=3013343;DOI=10.1182ood.V68.1.285.285

Kamesaki H.,Fukuhara S.,Tatsumi E.,Uchino H.,Yamabe H.,Miwa H.,Shirakawa S.,Hatanaka M.,Honjo T.

Cytochemical,immunologic,chromosomal,and molecular genetic analysis of a novel cell line derived from Hodgkin's disease.

Blood 68:285-292(1986)

PubMed=3359046;DOI=10.1182ood.V71.5.1382.1382

Hsu S.-M.,Zhao X.,Chakraborty S.,Liu Y.-F.,Whang-Peng J.,Lok M.-S.,Fukuhara S.

Reed-Sternberg cells in Hodgkin's cell lines HDLM,L-428,and KM-H2 are not actively replicating:lack of bromodeoxyuridine uptake by multinuclear cells in culture.

Blood 71:1382-1389(1988)

PubMed=2602653;DOI=10.1007/978-3-642-83781-4_9

Kamesaki H.,Fukuhara S.,Uchino H.,Nosaka T.

A new hypothesis on the cellular origin of Reed-Sternberg and Hodgkin cells based on the immunological and molecular genetic analysis of the KM-H2 line.

Recent Results Cancer Res.117:83-90(1989)

PubMed=2690233;DOI=10.1007/978-3-642-83781-4_5

Schaadt M.,Burrichter H.,Pfreundschuh M.,Schell-Frederick E.,Tesch H.,Fonatsch C.,Stein H.,Diehl V.

Biology of Hodgkin cell lines.

Recent Results Cancer Res.117:53-61(1989)

PubMed=8547074;DOI=10.1111/j.1365-2141.1995.tb05302.x

Siebert R.,Willers C.P.,Schramm A.,Fossa A.,Dresen I.M.G.,Uppenkamp M.,Nowrousian M.R.,Seeber S.,Opalka B.

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Br.J.Haematol.91:350-354(1995)

PubMed=8558920

Dirks W.G.,Zaborski M.,Jager K.,Challier C.,Shiota M.,Quentmeier H.,Drexler H.G.

The(2;5)(p23;q35)translocation in cell lines derived from malignant lymphomas:absence of t(2;5)in Hodgkin-analogous cell lines.

Leukemia 10:142-149(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In)ISBN 9780122219702;pp.1-733;Academic Press;London(2001)

PubMed=17065008;DOI=10.1080/10428190600667721

Feuerborn A.,Moritz C.,Von Bonin F.,Dobbelstein M.,Trumper L.,Sturzenhofecker B.,Kube D.

Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.

Leuk.Lymphoma 47:1932-1940(2006)

PubMed=18194364;DOI=10.1111/j.1399-0039.2007.01001.x

Witter K.,Mautner J.,Volgger A.,Zahn R.,Kauke T.

A novel HLA-DRB1 allele,HLA-DRB1*0465,was identified in a Hodgkin's lymphoma cell line.

Tissue Antigens 71:257-258(2008)

PubMed=20164919;DOI=10.1038/nature08768

Bignell G.R.,Greenman C.D.,Davies H.,Butler A.P.,Edkins S.,Andrews J.M.,Buck G.,Chen L.,Beare D.,Latimer C.,Widaa S.,Hinton J.,Fahey C.,Fu B.,Swamy S.,Dalgliesh G.L.,Teh B.T.,Deloukas P.,Yang F.,Campbell P.J.,Futreal P.A.,Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

PubMed=21368758;DOI=10.1038/nature09754

Steidl C.,Shah S.P.,Woolcock B.W.,Rui L.,Kawahara M.,Farinha P.,Johnson N.A.,Zhao Y.,Telenius A.,Neriah S.B.,McPherson A.,Meissner B.,Okoye U.C.,Diepstra A.,van den Berg A.,Sun M.,Leung G.,Jones S.J.,Connors J.M.,Huntsman D.G.,Savage K.J.,Rimsza L.M.,Horsman D.E.,Staudt L.M.,Steidl U.,Marra M.A.,Gascoyne R.D.

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

Nature 471:377-381(2011)

PubMed=22460905;DOI=10.1038/nature11003

Barretina J.G.,Caponigro G.,Stransky N.,Venkatesan K.,Margolin A.A.,Kim S.,Wilson C.J.,Lehar J.,Kryukov G.V.,Sonkin D.,Reddy A.,Liu M.,Murray L.,Berger M.F.,Monahan J.E.,Morais P.,Meltzer J.,Korejwa A.,Jane-Valbuena J.,Mapa F.A.,Thibault J.,Bric-Furlong E.,Raman P.,Shipway A.,Engels I.H.,Cheng J.,Yu G.K.,Yu J.,Aspesi P.Jr.,de Silva M.,Jagtap K.,Jones M.D.,Wang L.,Hatton C.,Palescandolo E.,Gupta S.,Mahan S.,Sougnez C.,Onofrio R.C.,Liefeld T.,MacConaill L.E.,Winckler W.,Reich M.,Li N.,Mesirov J.P.,Gabriel S.B.,Getz G.,Ardlie K.,Chan V.,Myer V.E.,Weber B.L.,Porter J.,Warmuth M.,Finan P.,Harris J.L.,Meyerson M.,Golub T.R.,Morrissey M.P.,Sellers W.R.,Schlegel R.,Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

PubMed=25355872;DOI=10.1128/JVI.02570-14

Cao S.,Strong M.J.,Wang X.,Moss W.N.,Concha M.,Lin Z.,O'Grady T.,Baddoo M.,Fewell C.,Renne R.,Flemington E.K.

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Bausch-Fluck D.,Hofmann A.,Bock T.,Frei A.P.,Cerciello F.,Jacobs A.,Moest H.,Omasits U.,Gundry R.L.,Yoon C.,Schiess R.,Schmidt A.,Mirkowska P.,Hartlova A.,Van Eyk J.E.,Bourquin J.-P.,Aebersold R.,Boheler K.R.,Zandstra P.,Wollscheid B.

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PLoS ONE 10:E0121314-E0121314(2015)

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Iorio F.,Knijnenburg T.A.,Vis D.J.,Bignell G.R.,Menden M.P.,Schubert M.,Aben N.,Goncalves E.,Barthorpe S.,Lightfoot H.,Cokelaer T.,Greninger P.,van Dyk E.,Chang H.,de Silva H.,Heyn H.,Deng X.,Egan R.K.,Liu Q.,Mironenko T.,Mitropoulos X.,Richardson L.,Wang J.,Zhang T.,Moran S.,Sayols S.,Soleimani M.,Tamborero D.,Lopez-Bigas N.,Ross-Macdonald P.,Esteller M.,Gray N.S.,Haber D.A.,Stratton M.R.,Benes C.H.,Wessels L.F.A.,Saez-Rodriguez J.,McDermott U.,Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

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