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Deposited As Sporotrichum sulfurescens van Beyma

Strain Designations 菌株別名 CBS 209.27 [DSM 1344]

Application 用途

Hydrolyzes 1,2-dihydronaphthalene

Hydrolyzes 1,2-epoxyindene

Hydrolyzes styrene oxide

Hydroxylates polycyclic enones Metabolizes phencyclidine Oxidizes arteether Oxidizes dialkylbenzen

Hydroxylates e Produces 2-deuterio-cycloalkanones

Produces 3-deuterio-cycloalkanones

Produces carbomycin derivatives magnamycin derivatives

Produces hydroxymethylpyridines (isomeric)

Produces leucomycin derivatives

Produces niddamycin derivatives

Hydroxylation of 7-azabrendane and 6-azatwistane derivatives

Hydroxylation of synthetic polycyclic enones Reduction of alpha, beta-unsaturated ketones Converts isosorbide dinitrate to isosorbide 5-mononitrate Transformation of pergolide to pergolide sulfoxide Glycosylation of 2,2,5,7,8-pentamethyl-6-hydroxychroman

Biosafety Level 生物安全等級(jí) 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format 提供形式 freeze-dried

Storage Conditions 生長(zhǎng)條件

Frozen 冷凍物 : -80℃ or colder

Freeze-Dried 凍干物 : 2℃ to 8℃

Live Culture 活菌 : See Propagation Section

Preceptrol® no

Medium 培養(yǎng)基 ATCC® Medium 200: YM agar or YM broth

 ATCC® Medium 324: Malt extract agar

 ATCC® Medium 336: Potato dextrose agar (PDA)

Growth Conditions 生長(zhǎng)條件

 Temperature 培養(yǎng)溫度 : 24℃ to 26℃

Atmosphere 需氧情況 : Typical aerobic

Sequenced Data 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence

GGTCTCCGTTGGTGAACCAGCGGAGGGATCATTACCGAGTTTTCAACTCCCTAACCCTTCTGTGAACCTAC

CTATCGTTGCTTCGGCGGACTCGCCCCAGCCCGGACGCGGACTGGACCAGCGGCCCGCCGGGGACCTC

AAACTCTTGTATTCCAGCATCTTCTGAATACGCCGCAAGGCAAAACAAATGAATCAAAACTTTCAACAACGG

ATCTCTTGGCTCTGGCATCGATGAAGAACGCAGCGAAACGCGATAAGTAATGTGAATTGCAGAATCCAGTG

AATCATCGAATCTTTGAACGCACATTGCGCCCGCCAGCATTCTGGCGGGCATGCCTGTTCGAGCGTCATTT

CAACCCTCGACCTCCCCTTGGGGAGGTCGGCGTTGGGGACCGGCAGCACACCGCCGGCCCTGAAATGGA

GTGGCGGCCCGTCCGCGGCGACCTCTGCGCAGTAATACAGCTCGCACCGGAACCCCGACGCGGCCACG

CCGTAAAACACCCAACTTCTGAACGTTGACCTCGAATCAGGTAGGACTACCCGCTGAACTTAAGCATATCAATAA D1D2

region of the 28S ribosomal RNA gene

ATATCAATAAGCGGAGGAAAAGAAACCAACAGGGATTGCCCCAGTAACGGCGAGTGAAGCGGCAACAGCTCA

AATTTGAAATCTGGCTCTCAGGGCCCGAGTTGTAATTTGTAGAGGATGCTTTTGGCGAGGTGCCTTCCGAGTT

CCCTGGAACGGGACGCCACAGAGGGTGAGAGCCCCGTATGGTCGGACACCGAGCCTCTGTAAAGCTCCTTC

GACGAGTCGAGTAGTTTGGGAATGCTGCTCAAAATGGGAGGTATATGTCTTCTAAAGCTAAATATTGGCCAGA

GACCGATAGCGCACAAGTAGAGTGATCGAAAGATGAAAAGCACTTTGAAAAGAGGGTTAAAAAGTACGTGAAA

TTGTTGAAAGGGAAGCGCCTATGACCAGACTTGCGCCCGGTGAATCACCCAGCGTTCTCGCTGGTGCACTTT

GCCGGGCACAGGCCAGCATCAGTTCAGCGCGGGGGAGAAAGGCTTCGGGAATGTGGCTCCCTCGGGAGTG

TTATAGCCCGCTGCGTAATGCCCTGCGCCGGACTGAGGTACGCGCATTGCAAGGATGCTGGCGTAATGGTCATCAGCGAC

RNA polymerase II largest subunit gene (RPB1)

CCATATAGAGCTGGCGAAACCTGTCTATCACCCTGGTTTCATCAAGAAAGTGAAAAAGGTTTTGGAGATTGTCTGCC

ACAACTGCAGCAAAGTGTTGGCCGATGAAGTTGGTCTTCCCTTTACTCCATGAAGCTCTGGAGCTTGCTGGATGCTA

ACGTGCATTATCAGAGCGATCCCGAATTCGTCACAGCTATTCATACTCGCGATCCGAAACTCCGATTCAAGCGCGTT

TGGGCCGTATGCAAGAAGAAGCGCAAATGCGAGAATGAGGAGCGGCAAGACAAGAATAAAGACGAAGAGTTCGCT

CCAGGTGTCAAGAACGTCGTTCTCGAAGGACATGGCGGATGTGGCAATATGCAGCCGCAGGTGAGACAGGCCGCGC

TGCAACTCAAAGCTGCCTTCGAGGTTACTTCGGAAGAGGGTCCCAAGAGGAAAGAGACGGTTAATATCAGCGCCGA

GATGGCGCATGGTATCCTTCGCCGCATCTCTGAGCGCGATCTGCACAATATTGGTCTTAACTCAGACTATGCTCGTCC

CGAGTGGATGATCATCACTGTCCTGCCTGTACCCCCTCCTCCCGTGCGTCCTAGTATTTCCATGGATGGTACTGGTAC

TGGCACGAGAAACGAGGATGATCTGACCTACAAGCTTGGTGACATTATCCGCGCCAACGGAAATGTCAAGCAGGCCA

TTCGTGAAGGATCACCGCAACACATCGCGCGTGATTTTGAGGAGCTGCTGCAGTACCATGTTGCCACC

Name of Depositor 寄存人 CBS

Chain of Custody 來(lái)源國(guó)家 ATCC <-- CBS <-- F.H. van Beyma

Isolation 分離源 Laboratory contaminant

References 參考文獻(xiàn) Ropenga JS, et al. Isosorbide dinitrate bioconversion by Beauveria strains: implication of glutathione transferase levels. Appl.Microbiol. Biotechnol. 31: 176-178, 1989.

Pedragosa-Moreau S, et al. Microbiological transformations. 28. Enantiocomplementary epoxide hydrolyses as a preparative access to both enantiomers of styrene oxide. J. Org. Chem. 58: 5533-5536, 1993.

Theriault RJ. Mycarosyl macrolide antibiotics. US Patent 3,784,447 dated Jan 8 1974 Taylor JJ. Further clarification of Sporotrichum species. Mycologia 62: 823, 1970.

Johnson RA, et al. Microbial oxygenation of dialkylbenzenes. Bioorg Chem 2: 99-110, 1973.

Kergomard A, et al. Microbiological reduction of alpha,beta-unsaturated ketones by Beauveria sulfurescens. J. Org. Chem. 47: 792-798, 1982.

Hu Y, et al. Microbial oxidataion of the antimalarial drug arteether. Bioorg. Chem. 20: 148-154, 1992.

Hufford CD, et al. Metabolism of phencyclidine by microorganisms. J. Pharm. Sci. 70: 155-158, 1981. PubMed: 7205218

Furstoss R, et al. Microbiological transformations 2. Hydroxylations of non activated carbons in globular type amides. Tetrahedron Lett 22: 445-448, 1981.

Dauphin G, et al. Microbiological synthesis and circular dichroism of optically active 2-deuterio-cycloalkanones. Tetrahedron Lett 21: 4275-4278, 1980.

Pedragosa-Moreau S, et al. Microbiological transformations. 31: Synthesis of enantiopure epoxides and vicinal diols using fungal epoxide hydrolase mediated hydrolysis. Tetrahedron Lett. 37: 3319-3322, 1996.

Dauphin G, et al. Microbial glycosylation of 2, 2, 5, 7, 8-pentamethyl- 6-hydroxychroman. Agric Biol Chem 53: 1433-1435, 1989.

Dauphin G, et al. Microbiological synthesis of optically active 3-deuterio-cycloalkanones. J. Chem. Soc. Chem. Commun. 1980: 318-319, 1980.

Smith RV, et al. Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone. J. Pharm. Sci. 72: 733-736, 1983. PubMed: 6684155

Modyanova LV, et al. Microbial transformation of nitrogen-containing heterocyclic compounds. I. Hydroxylation of isomeric monomethylpyridines and dimethylpyridines by microscopic fungi. Biotekhnologiya 3: 24-27, 1990.

Hammoumi A, et al. Microbial hydroxylation and functionalization of synthetic polycyclic enones. Tetrahedron Asymmetry 4: 1295-1306, 1993.

Xu Y, et al. Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana. Fungal Genet. Biol. 46: 353-364, 2009. PubMed: 19285149

Xu Y, et al. Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana. Chem. Biol. 15: 898-907, 2008. PubMed: 18804027

type strain of Sporotrichum sulfurescens